Decreased expression of HBV surface antigen (HBsAg) with sK122R and sV96A co-mutation is associated with an ineffective antibody response in a chronic hepatitis B patientArticle Published on 2023-07-012023-06-11 Journal: Infection, genetics and evolution : journal of mol [Category] B형 간염, [키워드] amino acid substitution Antibody Response antigenicity HBsAg sK122R sV96A. [DOI] 10.1016/j.meegid.2023.105431 PMC 바로가기
Amino Acid Variation at Hemagglutinin Position 193 Impacts the Properties of H9N2 Avian Influenza VirusArticle Published on 2023-02-282023-06-22 Journal: Journal of Virology [Category] 조류인플루엔자, [키워드] antigenicity H9N2 avian influenza virus HA variation position 193 receptor Replication Transmission. [DOI] 10.1128/jvi.01379-22 PMC 바로가기
Characterization of Influenza A(H1N1)pdm09 Viruses Isolated in the 2018-2019 and 2019-2020 Influenza Seasons in JapanArticle Published on 2023-02-142023-06-23 Journal: Viruses [Category] 신종인플루엔자, [키워드] antigenic change antigenicity ferret H1N1pdm09 Human influenza A virus. [DOI] 10.3390/v15020535 PMC 바로가기
A SARS-CoV-2 vaccine based on conjugation of SARS-CoV-2 RBD with IC28 peptide and mannanArticle Published on 2022-12-012022-11-15 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 adjuvant Antibody titer Antigen antigenicity Bacterial cause cellular immunity COVID-19 COVID-19 pandemic cytokine develop domain E. coli effective effective vaccine elicit elicited expected expressed feasibility humoral IFN-γ IL-10 IL-5 IMPROVE Interaction Ligand mannan neutralization neutralizing antibody organs peptide polysaccharide RBD RBD-specific IgG SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2. sera severe respiratory disease Th2-type Toxicity Vaccine Vaccine development viral infection virus [DOI] 10.1016/j.ijbiomac.2022.09.180 PMC 바로가기
Global dissemination of H5N1 influenza viruses bearing the clade 2.3.4.4b HA gene and biologic analysis of the ones detected in ChinaArticle Published on 2022-12-012023-06-14 Journal: Emerging Microbes & Infections [Category] Fulltext, 조류인플루엔자, [키워드] antigenicity Avian influenza virus clade2.3.4.4b Evolution H5N1 Pathogenicity. [DOI] 10.1080/22221751.2022.2088407 PMC 바로가기
Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] A570D A701V addition Affect affected antibodies antigenicity B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.617.2 BALB/c mice binding circulating cross-neutralization activity D1118H decrease Del Delta determine DNA vaccine Effects Efficiency elicited humoral immune response immune evasion immunized immunogen in vitro investigated K417N L18F Lineage Mutation NAbs Naturally neutralization Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron opposite overcome P681H Pseudotyped viruses reduced S982A SARS-CoV-2 SARS-CoV-2 variant sera significantly increased single mutation single mutations spike mutation T cell T cell responses T-cell Response T716I tested the RBD Transmissibility unlikely Vaccine vaccine immunogenicity vaccine immunogenicity. variants of concern viral entry viral infectivity VoC VOCs was determined weakened [DOI] 10.1038/s41423-022-00924-8 PMC 바로가기
Geographical distribution of SARS-CoV-2 amino acids mutations and the concomitant evolution of seven distinct clades in non-human hostsArticle Published on 2022-11-012022-11-16 Journal: Zoonoses and Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid analysed Analysis antigenicity clade Combination country Denmark distribution early stage Efficacy epidemiological Evolution exhibiting GISAID globe Host human SARS-CoV-2 indicate Latvia Local moderate MOST Mutation mutations Netherlands Non-human Non-human hosts ORF10 ORF3a pandemic pathogenicity Proteome evolution raised SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2. sequence Seven Surveillance sustained the SARS-CoV-2 genome the vaccine Transmissibility transmissions USA variant viral evolution Viral transmission viral variant Whole-genome sequence zoonotic zoonotic transmission [DOI] 10.1111/zph.12971 PMC 바로가기
Mutation of D201G near the receptor binding site significantly drives antigenic drift of circulating H9N2 subtype avian influenza virusArticle Published on 2022-11-012023-06-22 Journal: Transboundary and emerging diseases [Category] 조류인플루엔자, [키워드] antigenic drift antigenicity Avian influenza virus evolution. H9N2 RBS [DOI] 10.1111/tbed.14707 PMC 바로가기
Reduced B cell antigenicity of Omicron lowers host serologic responseArticle Published on 2022-10-182022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Antibody Response Antibody titer antigenicity B cell Breakthrough infection common cold coronavirus computational structural biology conserved CP: Immunology CP: Microbiology cross-reactivity deep learning ELISA Epitopes evade explain feature geometric Host Infection less Lower mechanism Mice immunization experiment mutated Neutralizing omicron Omicron variant of concern RBD RBS Receptor binding Receptor binding domain receptor binding site reduced reduction reduction in reveal SARS-CoV-2 Serologic response serological response serum Spike protein spike protein. trajectory vaccine-induced antibody variant variants viral evolution [DOI] 10.1016/j.celrep.2022.111512 PMC 바로가기
Virus-Like Particles of SARS-CoV-2 as Virus Surrogates: Morphology, Immunogenicity, and Internalization in Neuronal CellsArticle Published on 2022-10-142023-07-10 Journal: ACS Infectious Diseases [Category] COVID19(2023년), [키워드] antigenicity morphology SARS-CoV-2 U87-MG cells virus-like particles. [DOI] 10.1021/acsinfecdis.2c00217 PMC 바로가기